Estrogen Receptor/ERR
The proliferator-activated receptor gamma co-activator 1/estrogen-related receptor (PGC-1/ERR) transcriptional axis is involved in the control of mitochondrial biogenesis. The PGC-1/ERR pathway plays a dual role in cancer, depending on the specific cellular or tissue context and the environmental stimuli. The PGC-1/ERR axis has been shown to be essential for functional cancer cell motility and metastasis, leading to malignant transformation in breast and melanoma cancer progression. This pathway has also been shown to suppress prostate cancer progression and metastasis. The expression of PGC-1α is characterized by high expression levels in tissues, including kidney, skeletal muscle, liver, heart, neural tissue, and blood mononuclear cells, which exhibit greater energy demand caused by increased mitochondrial activity.57–59 The vast number of different tissues or physiological contexts in which PGC-1α is expressed reflects the large number of different NRs and TFs that are regulated by PGC-1α, possibly including all three estrogen-related receptors (ERRα, ERRβ, and ERRγ), SRC-1, and glucocorticoid receptors (GR), as well as the tumor suppressor p53, PPARγ, forkhead box protein O1 (FoxO1), hepatocyte nuclear factor 4α (HNF-4α), nuclear respiratory factor 1 (NRF-1), the cAMP response element binding protein (CREB), and the signal transducer and activator of transcription 6 (STAT-6).
Endocrinology/Hormones
Estrogen Receptor/ERR
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Prinaberel
产品货号 : M37942
cas no: 524684-52-4
Prinaberel (ERB-041) 是一种有效的选择性雌激素受体 β (ERβ) 激动剂,对人,大鼠和小鼠 ERβ 的 IC50 分别为 5.4、3.1 和 3.7 nM。 Prinaberel对 ERβ 的选择性是 ERα 的 200 倍以上。Prinaberel是有效的皮肤癌化学预防剂,可通过抑制 WNT/β-catenin 信号通路发挥作用。Prinaberel 诱导卵巢癌细胞凋亡 (apoptosis)。 -
Estrogen receptor antagonist 8
产品货号 : M37205
cas no: 2889370-92-5
Estrogen receptor antagonist 8 是一种有效的雌激素受体 ER 拮抗剂,具有体内抗子宫性质(EC50=4.160 μM) -
OBHSA
产品货号 : M37082
cas no: 1404508-27-5
OBHSA(Oxabicycloheptane sulfonamide) is a novel selective estrogen receptor depressant (SERD) that can be used to study breast cancer. -
SLU-PP-332
产品货号 : M36964
cas no: 303760-60-3
SLU-PP-332 是一种泛雌激素受体相关受体 (ERR) 激动剂,其对 ERRα, ERRβ 以及 ERRγ 的EC50 值分别为 98、230 以及 430 nM。SLUPP-332 可增强骨骼肌细胞系的线粒体功能和细胞呼吸。SLU-PP-332 具有研究代谢性疾病以及肌肉功能改善的潜力。 -
Palazestrant
产品货号 : M36480
cas no: 2092925-89-6
Palazestrant 是一种抗雌激素和抗肿瘤试剂。Palazestrant 与 HER2 抑制剂合用,可抑制 ER+/HER2+ 癌症。