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Aromatase
Aromatase is the sole member of family 19 of the P450 superfamily of enzymes, termed CYP19. Aromatase is a microsomal protein that is found throughout the vertebrate phylum, but the human gene is unique compared with the rest of its superfamily.The aromatase reaction employs 3 moles of oxygen and 3 moles of NADPH for every mole of steroid substrate metabolized. Aromatase shares a number of structural features common to all cytochrome P450 species.Aromatase is most widely known for its roles in reproduction and reproductive system diseases, and as a target for inhibitor therapy in estrogen-sensitive diseases including cancer, endometriosis, and leiomyoma.
References
1.Blakemore J,et al. Physiology (Bethesda). 2016 Jul;31(4):258-69
References
1.Blakemore J,et al. Physiology (Bethesda). 2016 Jul;31(4):258-69
Endocrinology/Hormones
Aromatase
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Minamestane
产品货号 : M36378
cas no: 105051-87-4
Minamestane is a novel irreversible aromatase inhibitor.Minamestane induces time-dependent inhibition of human placental aromatase with a half-life of 4 minutes and a K of 59 nM.Minamestane has antitumor activity.
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Finrozole
产品货号 : M34254
cas no: 160146-17-8
Finrozole (MPV-2213ad) 是一种非甾体类、口服活性、竞争性芳香酶 (aromatase) 抑制剂。Finrozole 可用于泌尿系统症状研究。
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Testolactone
产品货号 : M22381
cas no: 968-93-4
睾内酯是一种芳香酶抑制剂，阻止雄激素向雌激素的转化。它是具有抗肿瘤活性的孕激素衍生物。
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Geraniin
产品货号 : M18888
cas no: 60976-49-0
Geraniin 对 OVX 诱导的大鼠骨质疏松症具有保护作用。 Geraniin 在体外和体内对癌细胞具有细胞毒活性。
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Flavokawain A
产品货号 : M18443
cas no: 3420-72-2
Flavokawain A 具有抗肿瘤活性，例如抑制裸鼠模型中膀胱肿瘤细胞的生长，防止非肌层浸润性尿路上皮细胞癌的复发和进展。
