Ferroptosis
Ferroptosis is an iron- and ROS-dependent form of regulated cell death (RCD). Ferroptosis is distinct from other forms of RCD at morphological, biochemical, and genetic levels. It is characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. It can be induced by experimental compounds (e.g., erastin, Ras-selective lethal small molecule, and buthionine sulfoximine) or clinical drugs (e.g., sulfasalazine, sorafenib, and artesunate) in cancer cells and certain normal cells. Several molecules (e.g., VDAC2/3, glutathione peroxidase (GPX4), heat shock protein beta-1 (HSPB1), nuclear factor E2-related factor 2 (NRF2), NADPH oxidase (NOX), p53, and SLC7A11) regulate ferroptosis by directly or indirectly targeting iron metabolism and lipid peroxidation. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes such as cancer cell death, tissue injury, and T-cell immunity.
References
1.Xie Y, et al. Cell Death Differ. 2016;23(3):369–379.
References
1.Xie Y, et al. Cell Death Differ. 2016;23(3):369–379.
Apoptosis
Ferroptosis
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FSEN1
产品货号 : M37112
cas no: 862808-01-3
FSEN1 是一种有效的非竞争性 FSP1 抑制剂,IC50 值为 313 nM。 FSEN1 通过抑制 FSP1 触发癌细胞中的铁死亡。FSEN1 可用于癌症研究。 -
ROS-generating?agent?1
产品货号 : M37110
cas no: 2369030-41-9
ROS-generating agent 1 (Compound 2c) 共价修饰 TrxR 的 Sec-498 残基以生成 ROS。ROS-generating agent 1 降低细胞内 TrxR 蛋白水平。ROS-generating agent 1 导致 NCI-H460 细胞中 ROS 依赖的性细胞凋亡 (apoptosis) 和铁死亡 (ferroptosis)。ROS-generating agent 1 具有抗癌活性。 -
BCP-T.A
产品货号 : M35673
cas no: 2786829-70-5
BCP-T.A,一种杂环亲电子试剂,通过与 GPX4 结合而有效地诱导铁死亡 (ferroptosis)。BCP-T.A 是一种点击化学试剂。它含有 Alkyne 基团,可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。 -
MMRi62
产品货号 : M35377
cas no: 352693-80-2
MMRi62 是一种铁死亡 (ferroptosis) 诱导剂,靶向 MDM2-MDM4(抑癌基因 p53 负调控因子)。MMRi62 对胰腺导管腺癌 (PDAC) 细胞显示出 p53独立的促凋亡 (apoptosis) 活性,并诱导其自噬 (autophagy)。MMRi62 诱导铁死亡,伴随着活性氧增加和铁蛋白重链 (FTH1) 溶酶体降解。MMRi62 还可导致突变型 p53 的蛋白酶体降解,并对具有 KRAS 和 TP53 高频突变特征的原位异种移植 PDAC 小鼠模型具有体内药效。 -
FINO2
产品货号 : M35322
cas no: 869298-31-7
INO2 是一种有效的 ferroptosis 诱导剂。FINO2 抑制 GPX4 活性。FINO2 是一种稳定的氧化剂,将铁氧化为氧化亚铁并在不同的 pH 值下保持稳定。FINO2 引起广泛的脂质过氧化。