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DAPK
Death associated protein kinase 1 (DAPK) is a serine/threonine kinase involved in the regulation of multiple cellular processes such as apoptosis, autophagy, cell migration, membrane blebbing, etc. Autophosphorylation of DAPK at Ser308 inhibits its catalytic activity and dephosphorylation at this site is an important marker for DAPK activation. The mouse embryonic fibroblasts (MEFs) from DAPK-/- mice showed decreased apoptotic response to overexpression of oncogenes such as c-myc and E2F due to the insufficient activation of the p19ARF-p53 pathway. DAPK is pro-apoptotic in response to both TNF-a and shear stress alone. The dysfunction of DAPK or DAPK related signalling pathways have been linked with various diseases such as cancer, stroke, inflammation and atherosclerosis.
References
1.Huang Y,et al. Apoptosis. 2014 Feb;19(2):371-86.
References
1.Huang Y,et al. Apoptosis. 2014 Feb;19(2):371-86.
Apoptosis
DAPK
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DAPK-IN-2
产品货号 : M36987
cas no: 304000-05-3
DAPK-IN-2 是一种 DAPK 抑制剂。 DAPK-IN-2 可用于脑梗死和缺血性疾病的研究。
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TC-DAPK 6
产品货号 : M33509
cas no: 315694-89-4
TC-DAPK 6 是一种有效的ATP竞争性的选择性 DAPK 抑制剂，作用于 DAPK1 和 DAPK3，IC50 分别为 69 和 225 nM。
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DRAK2-IN-16
产品货号 : M16339
cas no: 871837-60-4
DRAK2-IN-116 是一种有效的选择性 DRAK2 抑制剂，IC50 为 3 nM。
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HS148
产品货号 : M12969
cas no: 1892595-16-2
HS148（DAPK3 抑制剂 HS148）是一种选择性 DAPK3 抑制剂，Ki 为 119 nM。
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HS94
产品货号 : M12968
cas no: 1892594-93-2
HS94（DAPK3 抑制剂 HS94）是一种选择性 DAPK3 抑制剂，Ki 为 126 nM，选择性是 Pim 激酶的 20 倍以上。
