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IL Receptor
Interleukin receptors are a family of cytokine receptors for interleukins. They belong to the immunoglobulin superfamily.There are many kinds of IL-receptors such as interleukin-1 receptor, interleukin-6 receptor, interleukin-10 receptor, interleukin-12 receptor and others. Interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. The function of the immune system depends in a large part on interleukins and interleukin receptors. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. It has been reported that some interleukin receptors (ILRs) are highly expressed in many tumorous cells because they can contribute to malignant progression and apoptosis resistance of various cancer types including glioma (Kioi et al., 2008). Among these ILRs, interleukin-13 receptor (IL-13R) has already been used as a targeting site for mediating nano-enabled delivery systems to glioma.
References
1.Shanshan Wang et al. in Brain Targeted Drug Delivery System, 2019.
References
1.Shanshan Wang et al. in Brain Targeted Drug Delivery System, 2019.
Apoptosis
IL Receptor
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Nothofagin
产品货号 : M37740
cas no: 11023-94-2
Nothofagin 是一种二氢查尔酮，是从如意宝 (Aspalathus linearis) 中分离得到的。Nothofagin 通过阻断钙 (calcium) 内流来下调 NF-κB 的转运。Nothofagin 具有抗氧化活性，可改善各种炎症反应，例如脓毒症反应和血管炎症。
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Secukinumab B
产品货号 : M37701
cas no: 1229022-83-6
Anti-Human IL-17A是一种全人抗白细胞介素 17A单克隆抗体。Anti-Human IL-17A可用于银屑病发病机制研究。
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Pascolizumab
产品货号 : M36890
cas no: 331243-22-2
Pascolizumab (SB-240683) 是一种人源化抗 IL-4 单克隆抗体。Pascolizumab 具有哮喘研究的潜力。
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MyD88-IN-1
产品货号 : M36865
cas no: 2911609-80-6
MyD88-IN-1 是一种有效的 MyD88 抑制剂。MyD88-IN-1 抑制 TLR4 和 MyD88 的相互作用并抑制 NF-κB 通路。MyD88-IN-1 可用于癌症和炎症的研究。
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Netakimab
产品货号 : M36816
cas no: 1796570-08-5
Netakimab 是一种抗 IL-17 单克隆抗体。Nerelimomab 可用于强直性脊柱炎、银屑病关节炎、中重度斑块状银屑病的研究。
