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JAK
Janus kinases (JAKs) are cytoplasmic tyrosine kinases. They link cytokine signalling from membrane receptors to signal transducers and activators of transcription (STAT) transcription factors. Four JAK family members are known: JAK1, JAK2, JAK3 and TYK2. The JAK–STAT signalling paradigm was discovered two decades ago, providing a breakthrough in the understanding of cytokine biology . JAKs associate with a proline-rich region in each intracellular domain, which is adjacent to the cell membrane and called a box1/box2 region. After the receptor associates with its respective cytokine/ligand, it goes through a conformational change, bringing the two JAKs close enough to phosphorylate each other.
Angiogenesis
JAK
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Axltide
产品货号 : M30411
cas no: 143364-95-8
Axltide is based on the mouse Insulin receptor substrate 1 (amino acid 979-989).Peptide sequence (KKSRGDYMTMQIG) is based on the mouse Insulin receptor substrate 1 (amino acid 979-989).
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Tyrosine Protein Kinase JAK2 Phospho-Tyr8, 9
产品货号 : M29968
cas no: 247171-44-4
Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide corresponding to amino acids 475 to 491 of mouse JAK2.
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Povorcitinib phosphate
产品货号 : M28210
cas no: 1637677-33-8
Povorcitinib 磷酸盐是一种选择性 JAK1 抑制剂，可用于治疗皮肤红斑狼疮和扁平苔藓的研究。
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Fosifidancitinib
产品货号 : M28194
cas no: 1237168-58-9
Fosifidancitinib 是 JAK 1 和 JAK 3 的有效抑制剂。
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JAK2-IN-7
产品货号 : M28060
cas no: 2593402-36-7
JAK2-IN-7 是一种选择性 JAK2 抑制剂，对 JAK2、SET-2 和 Ba/F3V617F 细胞的 IC50 分别为 3、11.7 和 41 nM。 JAK2-IN-7 的选择性是 JAK1、JAK3、FLT3 的 14 倍以上。 JAK2-IN-7 刺激细胞周期停滞在 G0/G1 期并诱导肿瘤细胞凋亡。抗肿瘤活性。
