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VEGFR
Blood vessels are required for the growth and dissemination of a solid tumor. There are numerous growth factors involved in tumor angiogenesis, but foremost among them is the family of vascular endothelial growth factors (VEGFs). The VEGF family includes VEGFA, VEGFB, VEGFC, VEGFD, and placenta growth factor (PGF). These ligands bind with different affinities to three endothelial receptor tyrosine kinases (RTKs), such as VEGFR1, VEGFR2, and VEGFR3, as well as co-receptors, including neuropilins and heparan sulfate proteoglycans. VEGFA has been studied more than other family members and is a critical regulator of angiogenesis. VEGFA is usually referred to simply as VEGF. Vascular endothelial growth factor promotes tumor angiogenesis through stimulating the proliferation and survival of endothelial cells and also by increasing the permeability of vessels and recruiting vascular precursor cells from the bone marrow. VEGF has some direct effects on cancer cells or cancer stem cells. VEGF might promote cancer cell proliferation through the activation of VEGFR1 signaling. VEGFA/neuropilin-1 pathway conferred cancer stemness via the activation of the Wnt/β-catenin axis in breast cancer cells, also promotes tumor-initiating cell self-renewal through VEGFR2/STAT3 signaling.
References
1.Yang J,et al. Front Immunol. 2018;9:978.
References
1.Yang J,et al. Front Immunol. 2018;9:978.
Angiogenesis
VEGFR
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TIE-2/VEGFR-2 kinase-IN-5
产品货号 : M37252
cas no: 1014407-83-0
TIE-2/VEGFR-2 kinase-IN-5 是一个抗血管生成剂。TIE-2/VEGFR-2 kinase-IN-5 也是一种有效的 TIE-2 和 VEGFR-2 酪氨酸激酶受体抑制剂， pIC50 值分别为 7.78 nM 和 8.11 nM。TIE-2/VEGFR-2 kinase-IN-5 可用于血管生成的研究。
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Icrucumab
产品货号 : M36749
cas no: 1024603-92-6
Icrucumab (Anti-VEGFR1/FLT1 Reference Antibody; IMC-18F1) 是一种人源化的抗 VEGFR-1 IgG1 单克隆抗体。Icrucumab 具有用于晚期实体瘤研究的潜力。
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Parsatuzumab
产品货号 : M36701
cas no: 1312797-14-0
Parsatuzumab (Anti-EGFL7; RG 7414) 是一种人源化单克隆抗体，作为免疫调节剂与 EGFL7 结合。Parsatuzumab 选择性阻断 EGFL7 与内皮细胞之间的相互作用，可能抑制血管再生，降低血管内皮生长因子 (VEGF) 抑制。
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GW297361
产品货号 : M36628
cas no: 388627-21-2
GW297361 是一种氧化吲哚 CDK 抑制剂，在细胞中引起 Pho85 选择性反应。GW297361体外抑制酵母 Cdk1 和 Pho85， IC50 分别为 20 nM 和 400 nM。
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VEGFR-3-IN-1
产品货号 : M36479
cas no: 2756668-73-0
VEGFR-3-IN-1 是一种有效的高选择性 VEGFR3 抑制剂，其 IC50 为 110.4 nM。VEGFR-3-IN-1 通过使 VEGFR3 信号通路失活，显著抑制 VEGF-C 诱导人真皮淋巴管内皮细胞 (HDLEC)、MDA-MB-231 和 MDA-MB-436 细胞的增殖和迁移，并且能有效抑制乳腺癌的生长。
