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Syk
Spleen tyrosine kinase (Syk) is a cytosolic non-receptor protein tyrosine kinase (PTK). Syk contains two N-terminal SH2 domains and one Cterminal tyrosine kinase domain. The SH2 domains of Syk bind to immunoreceptor tyrosine-based activation motifs (ITAMs), leading to Syk activation. Syk protein lacks myristoylation site, therefore does not attach directly to the cell membrane.Syk was recognized as a critical element in the BCR signaling pathway. Syk along with other BCR signaling molecules, Bruton tyrosine kinase (BTK), PI3K delta (PI3Kδ), and tumor necrosis factor (TNF) superfamily receptors was also found to be involved in signal transduction independent from the BCR. Syk is expressed primarily in hematopoietic cells like Bcells, monocytes, macrophages, mast cells, and neutrophils. Syk was recognized to be a potential target for the treatment of various hematologic cancers, autoimmune disorders, and other inflammatory states.
References
1.Liu D,et al. J Hematol Oncol. 2017;10(1):145.
References
1.Liu D,et al. J Hematol Oncol. 2017;10(1):145.
Angiogenesis
Syk
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Sovleplenib
产品货号 : M34619
cas no: 1415792-84-5
Sovleplenib (HMPL-523) 是一种高效的、可口服的选择性 SYK 抑制剂，IC50 为 25 nM。具有抗肿瘤活性。Sovleplenib 可用于免疫性血小板减少症（ITP）的研究。
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TC-S 7003
产品货号 : M33407
cas no: 847950-09-8
Lck Inhibitor 是一种有效的口服活性淋巴细胞特异性激酶 (Lck) 抑制剂，对 Lck，Lyn，Src 和 Syk 激酶的 IC50 分别为 7、2.1、4.2 和 200 nM。与 MAPK，CDK 和 RSK 家族代表相比，Lck Inhibitor 对 Lck 的选择性高出 1000 倍以上。Lck Inhibitor 抑制 T 细胞增殖和关节炎模型。
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Syk-IN-3
产品货号 : M33132
cas no: 1312534-69-2
Syk-IN-3，一种有效的脾酪氨酸激酶 (Syk) 抑制剂，IC50为 1nM，详情请见专利 WO2011075515A1，化合物 example 152。
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Cevidoplenib dimesylate hydrochloride
产品货号 : M28906
cas no: 269062-93-3
Cevidoplenib dimesylate HydroHClide 是一种脾酪氨酸激酶 (Syk) 抑制剂，具有潜在的免疫调节和抗炎特性。
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Cevidoplenib dimesylate
产品货号 : M28223
cas no: 2043659-93-2
Cevidoplenib dimesylate 是一种脾酪氨酸激酶 (Syk) 抑制剂，具有抗炎和免疫调节特性。
