WAY-100635
CAS No. 162760-96-5
WAY-100635 ( WAY 100635;WAY100635 )
产品货号. M12413 CAS No. 162760-96-5
A potent and selective 5-HT1A receptor antagonist; also acts as potent full agonist at the D4 receptor.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥478 | 有现货 |
|
50MG | ¥2884 | 有现货 |
|
100MG | ¥5095 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称WAY-100635
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述A potent and selective 5-HT1A receptor antagonist; also acts as potent full agonist at the D4 receptor.
-
产品描述A potent and selective 5-HT1A receptor antagonist; also acts as potent full agonist at the D4 receptor; completely prevents not only the hyperpolarization, with an IC50 of 1.3 nM, but also the decrease in membrane input resistance produced by 5-HT and 5-carboxamidotryptamine with IC50 of 22.5 μM and 50 nM, respectively. Anxiety Phase 1 Discontinued
-
同义词WAY 100635;WAY100635
-
通路Endocrinology/Hormones
-
靶点5-HT Receptor
-
受体5-HT Receptor
-
研究领域Neurological Disease
-
适应症Anxiety
化学信息
-
CAS Number162760-96-5
-
分子量422.56
-
分子式C25H34N4O2
-
纯度>98% (HPLC)
-
溶解度10 mM in DMSO
-
SMILESO=C(C1CCCCC1)N(CCN2CCN(C3=CC=CC=C3OC)CC2)C4=NC=CC=C4
-
化学全称N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cyclohexanecarboxamide
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Corradetti R, et al. J Pharmacol Exp Ther. 1996 Aug;278(2):679-88.
2. Fornal CA, et al. J Pharmacol Exp Ther. 1996 Aug;278(2):752-62.
3. García G, et al. Eur J Med Chem. 2014 Oct 6;85:795-806.
2. Fornal CA, et al. J Pharmacol Exp Ther. 1996 Aug;278(2):752-62.
3. García G, et al. Eur J Med Chem. 2014 Oct 6;85:795-806.
产品手册
关联产品
-
Urapidil
Urapidil is a sympatholytic antihypertensive drug. It acts as an α1-adrenoceptor antagonist and as an 5-HT1A receptor agonist.
-
PF-04781340
A potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability.
-
Temanogrel
Temanogrel is a highly selective antagonist of the 5-HT2A receptor (Ki: 4.9 nM).