Trk-IN-9

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Trk-IN-9 (Compound 12) 是一种有效的 TRK 抑制剂。Trk-IN-9 抑制 Km-12 细胞系的增殖。Trk-IN-9 以浓度依赖性方式诱导 Km-12 细胞凋亡。Trk-IN-9 抑制 TRK 的磷酸化以阻断下游通路。Trk-IN-9具有研究NTRK融合癌症的潜力。

Trk-IN-9 (Compound 12) is a potent inhibitor of TRK. Trk-IN-9 inhibits the proliferation of Km-12 cell lines. Trk-IN-9 induces the apoptosis of Km-12 cells in a concentration-dependent manner. Trk-IN-9 inhibits the phosphorylation of TRK to block downstream pathways. Trk-IN-9 has the potential for the research of NTRK-fusion cancers.

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Apoptosis

Apoptosis

Apoptosis | Trk receptor

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2758623-12-8

454.93

C23H24ClFN6O

>98% (HPLC)

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N(C=1N=C(NCC2=CC(F)=CC=C2)C(Cl)=CN1)C3=CC(C(N[C@@H]4CCCNC4)=O)=CC=C3

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(-20℃)

With Ice Pack

≥ 2 years