RA-9
CAS No. 919091-63-7
RA-9 ( —— )
产品货号. M22045 CAS No. 919091-63-7
RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥365 | 有现货 |
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10MG | ¥616 | 有现货 |
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25MG | ¥1077 | 有现货 |
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50MG | ¥1596 | 有现货 |
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100MG | ¥2495 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称RA-9
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity.
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产品描述RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 selectively induces apoptosis in ovarian cancer cell lines.The characterization of RA-9 as a small-molecule inhibitor of proteasome-associated DUBs.?Treatment with RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors.?Loss of cell viability following RA-9 exposure is associated with an unfolded protein response as mechanism to compensate for unsustainable levels of proteotoxic stress.?In vivo treatment with RA-9 retards tumor growth, increases overall survival, and was well tolerated by the host.
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同义词——
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通路Apoptosis
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靶点Apoptosis
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受体Apoptosis;deubiquitinating enzymes (DUBs)
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研究领域——
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适应症——
化学信息
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CAS Number919091-63-7
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分子量365.34
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分子式C19H15N3O5
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纯度>98% (HPLC)
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溶解度DMSO:4 mg/mL (10.95 mM; ultrasonic and warming and heat to 80°C)
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SMILES[O-][N+](=O)c1ccc(\C=C2/CNC\C(=C/c3ccc(cc3)[N+]([O-])=O)C2=O)cc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Coughlin K , Anchoori R , Iizuka Y , et al. Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein responses.[J]. Clinical Cancer Research An Official Journal of the American Association for Cancer Research, 2014, 20(12):3174-86.
产品手册
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