SNG-1153 ( SNG 1153 | SNG1153 )

产品货号. M11901 CAS No. 1446712-19-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SNG-1153
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

淫羊藿素衍生物，可抑制肺 CSC 的生长。
产品描述

A derivate of icaritin that inhibits the growth of lung CSCs; inhibits the tumorsphere formation and decreases CD133-positive (lung CSC marker) cancer cells, attenuates tumor formation in NOD/SCID mice; induces β-catenin phosphorylation and down-regulated β-catenin; targets abnormal ERα36 activity, inhibits cell growth and induces apoptosis of BCR-ABL+ leukemic cells, particularly BCR-ABL-T315I mutant cells; effectively eliminates infiltrated BCR-ABL+ blast cells and enhances survival of mice combined with dasatinib.Breast Cancer Preclinical.
体外实验

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体内实验

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同义词

SNG 1153 | SNG1153
通路

Endocrinology/Hormones
靶点

Estrogen Receptor/ERR
受体

Estrogen Receptor/ERR
研究领域

Cancer
适应症

Breast Cancer

CAS Number

1446712-19-1
分子量

406.3519
分子式

C21H17F3O5
纯度

>98% (HPLC)
溶解度

DMSO: ≥ 32 mg/mL
SMILES

O=C1C(O)=C(C2=CC=C(C(F)(F)F)C=C2)OC3=C1C(O)=CC(O)=C3C/C=C(C)\C
化学全称

4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-8-(3-methyl-2-buten-1-yl)-2-[4-(trifluoromethyl)phenyl]-

1. Liu S, et al. Oncotarget. 2016 Jul 19;7(29):45158-45170. 2. Chen M, et al. Oncotarget. 2017 Jul 4;8(27):43662-43677.

计算器

产品手册

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