CMP8

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CMP8 是雌激素受体的选择性配体。 CMP8 与突变雌激素受体配体结合域 (ERLBD) 结合。

CMP8 is a selective ligand for estrogen receptor. CMP8 binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 has IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, respectively.(In Vivo):CMP8 is dosed in male Balb-c mice (4 mg/kg, ip). In mammalian cells, the plasma concentration after 4 h is 1.5-fold its EC50. It has a Cmax of 0.5 μM after 30 min.

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CMP8 (Compound 20h) is dosed in male Balb-c mice (4 mg/kg, ip). The plasma concentration after 4 h is 1.5-fold its EC50 in mammalian cells with a Cmax of 0.5 μM after 30 min.

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Endocrinology/Hormones

Estrogen Receptor/ERR

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851107-28-3

528.09

C33H34ClNO3

>98% (HPLC)

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Oc1ccc2C3=C(C(=O)CCC3(Cc3ccc(Cl)cc3)Cc2c1)c1ccc(OCCN2CCCCC2)cc1

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(-20℃)

With Ice Pack

≥ 2 years