Mestranol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Mestranol 是一种非活性的前体，在转化为炔雌醇 (EE) 时具有生物活性。Mestranol是一种雌激素受体 (estrogen receptor) 激动剂。动物实验中，Mestranol 可以与黄体酮联合使用，Mestranol 可用于更年期激素或月经紊乱的研究。

Mestranol is the 3-methyl ether of ethinylestradiol. It was the estrogen used in many of the first oral contraceptives. It is a biologically inactive prodrug of ethinylestradiol to which it is demethylated in the liver with a conversion efficiency of 70%.(In Vitro):Mestranol is a low potency synthetic estrogen that has been shown to be much more stable than 17β-Estradiol(HY-B0141) in hepatoma cell culture.Mestranol (10 μM; 6 days) stimulates the growth of ERpositive MCF-7 WS8 cells up to 250% of control levels, growth stimulation could be partially reversed by tamoxifen.However, in Hep G2 hepatoma cells, Mestranol (10 μM; 6 days) inhibits the growth of Hep 3B cells by 40% compared to control cells. Mestranol alone or cotreatment with tamoxifen both can inhibit cell growth. And cotreatment exhibits an additive effect with tamoxifen on growth inhibition.

Mestranol is a low potency synthetic estrogen that has been shown to be much more stable than 17β-Estradiol(HY-B0141) in hepatoma cell culture.Mestranol (10 μM; 6 days) stimulates the growth ofERpositive MCF-7 WS8 cells up to 250% of control levels, growth stimulation could be partially reversed by tamoxifen.However, in Hep G2 hepatoma cells, Mestranol (10 μM; 6 days) inhibits the growth of Hep 3B cells by 40% compared to control cells. Mestranol alone or cotreatment with tamoxifen both can inhibit cell growth. And cotreatment exhibits an additive effect with tamoxifen on growth inhibition.

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EE 3-ME | Ethynyl Estradiol 3-methyl ether | NSC 84032 | SC-475 | Δ-MVE

Endocrinology/Hormones

Estrogen Receptor/ERR

ER

Endocrinology

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72-33-3

310.43

C21H26O2

>98% (HPLC)

Ethanol: 25 mg/mL (80.53 mM); DMSO: 15 mg/mL (48.32 mM)

CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)OC

17-ethynyl-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol

(-20℃)

With Ice Pack

≥ 2 years