Phenidone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Phenidone 是环氧合酶和脂氧合酶的双重抑制剂，通过抑制其靶酶来改善实验性自身免疫性脑脊髓炎大鼠的瘫痪。

Phenidone is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat.(In Vitro):Western blot analysis showed that phenidone significantly inhibited the increases in COX-1/-2 and 5-LOX in the spinal cords of rats with EAE.(In Vivo):Lipoxygenase inhibitor phenidone markedly attenuates angiotensin II (AII) induced vascular contractility. Phenidone was also shown to inhibit the formation of vascular lipoxygenase products and to reduce blood pressure in the AII-dependent renovascular hypertensive rat.

Phenidone significantly inhibits the increases in COX-1/-2 and 5-LOX in the spinal cords of rats with experimental autoimmune encephalomyelitis (EAE).

Phenidone inhibits the formation of vascular lipoxygenase products and to reduce blood pressure in the AII-dependent renovascular hypertensive rat.

1-phenyl-3-pyrazolidinone

Immunology/Inflammation

Lipoxygenase

——

——

——

92-43-3

162.192

C9H10N2O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (616.56 mM)

OC1=NN(CC1)c1ccccc1

——

(-20℃)

With Ice Pack

≥ 2 years