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BI-0115
CAS No. 4929-23-1
BI-0115 ( —— )
产品货号. M24450 CAS No. 4929-23-1
BI-0115 是一种选择性 LOX-1 小分子抑制剂，可阻止细胞摄取 oxLDL。它的结合通过形成同二聚配体结合域的二聚体来触发受体抑制。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1936 | 有现货 |
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| 10MG | ￥2876 | 有现货 |
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| 25MG | ￥4779 | 有现货 |
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| 50MG | ￥6958 | 有现货 |
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| 100MG | ￥9558 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称BI-0115
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述BI-0115 是一种选择性 LOX-1 小分子抑制剂，可阻止细胞摄取 oxLDL。它的结合通过形成同二聚配体结合域的二聚体来触发受体抑制。
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产品描述BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX-1 bound to BI-0115 shows that inter-ligand interactions at the receptor interfaces are key to the formation of the receptor tetramer thereby blocking oxLDL binding.
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体外实验BI-0115 efficiently reduces oxLDL internalization in the cellular context. The IC50 values of the cellular assay (5.4?μM) are in good agreement with the determined Kd values in SPR (4.3?μM) and ITC (6.99?μM).
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体内实验——
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同义词——
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通路Immunology/Inflammation
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靶点Lipoxygenase
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受体LOX-1
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研究领域——
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适应症——
化学信息
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CAS Number4929-23-1
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分子量287.747
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分子式C15H14ClN3O
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纯度>98% (HPLC)
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溶解度DMSO:10 mM
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SMILESO=C1N(CCC)C2=CC=CN=C2NC3=C1C=CC(Cl)=C3
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册
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