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PTC725
CAS No. 1248581-07-8
PTC725 ( PTC 725 )
产品货号. M11004 CAS No. 1248581-07-8
PTC725 is a potent, selective, and orally bioavailable inhibitor of HCV NS4B, inhibits HCV 1b (Con1) replicons with EC50 of 1.7 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥9477 | 有现货 |
|
| 50MG | ￥19278 | 有现货 |
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| 100MG | ￥25110 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PTC725
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PTC725 is a potent, selective, and orally bioavailable inhibitor of HCV NS4B, inhibits HCV 1b (Con1) replicons with EC50 of 1.7 nM.
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产品描述PTC725 is a potent, selective, and orally bioavailable inhibitor of HCV NS4B, inhibits HCV 1b (Con1) replicons with EC50 of 1.7 nM; displays a selectivity index of >5,000 with respect to cellular GAPDH, and >1,000-fold selectivity window with respect to cytotoxicity; retains fully activity against HCV replicon mutants that are resistant to inhibitors of NS3 protease and NS5B polymerase, demonstrates synergistic affect in combination with alpha interferon in vivo.
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同义词PTC 725
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通路Microbiology/Virology
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靶点HCV
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受体HCV
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研究领域——
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适应症——
化学信息
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CAS Number1248581-07-8
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分子量518.49
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分子式C23H18F4N6O2S
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纯度>98% (HPLC)
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溶解度——
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SMILESO=S(C1=CC=C(C(N2C3=NC=CC=N3)=C(C#N)C4=C2C=C(CC)C(F)=C4)N=C1)(N[C@@H](C)C(F)(F)F)=O
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化学全称(S)-6-(3-Cyano-6-ethyl-5-fluoro-1-(pyrimidin-2-yl)-1H-indol-2-yl)-N-(1,1,1-trifluoropropan-2-yl)pyridine-3-sulfonamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Gu Z, et al. Antimicrob Agents Chemother. 2013 Jul;57(7):3250-61.
2. Zhang N, et al. J Med Chem. 2014 Mar 13;57(5):2121-35.
3. Graci JD, et al. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7060-7066.
2. Zhang N, et al. J Med Chem. 2014 Mar 13;57(5):2121-35.
3. Graci JD, et al. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7060-7066.
产品手册
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