021-51111890
购物车（0）
sales@molnova.cn
NoxA1ds
CAS No. 1435893-78-9
NoxA1ds ( —— )
产品货号. M30628 CAS No. 1435893-78-9
Potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. Cell permeable.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
生物学信息
-
产品名称NoxA1ds
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述Potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. Cell permeable.
-
产品描述Potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. Cell permeable.
-
体外实验——
-
体内实验——
-
同义词——
-
通路Membrane Transporter/Ion Channel
-
靶点NADPH
-
受体——
-
研究领域——
-
适应症——
化学信息
-
CAS Number1435893-78-9
-
分子量1125.33
-
分子式C50H88N14O15
-
纯度>98% (HPLC)
-
溶解度water:2 mg/mL
-
SMILES[H]N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Ranayhossaini et al (2013) Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration. J.Biol.Chem. 288 36437 PMID:
产品手册
关联产品
-
GSK2194069
GSK2194069 是脂肪酸合成酶 (FASN) 的 β-酮基还原酶 (KR) 的有效抑制剂，IC50 为 7.7 nM。GSK2194069 通过作用乙酰乙酰辅酶 A、NADPH (IC50 或 Ki 分别为 4.8 nM 和 5.6 nM) ，抑制表达 FAS 的癌细胞。
-
NoxA1ds
Potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. Cell permeable.
-
5-Heneicosylresorcin...
5-Heneicosylresorcinol 对 RBL-2H3 细胞释放 β-hexosaminidase 具有抑制作用，还可以防止 3T3-L1 细胞中甘油三酯的积累。 5-Henecosylresorcinol 对 Panagrellus redivivus、Caenothabditis elegans 和 Bursaphelenchus xylophilus 线虫具有杀线虫活性，ED50 值分别为 80、30 和 180 ug/mL。
