5-Heneicosylresorcinol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

5-Heneicosylresorcinol 对 RBL-2H3 细胞释放 β-hexosaminidase 具有抑制作用，还可以防止 3T3-L1 细胞中甘油三酯的积累。 5-Henecosylresorcinol 对 Panagrellus redivivus、Caenothabditis elegans 和 Bursaphelenchus xylophilus 线虫具有杀线虫活性，ED50 值分别为 80、30 和 180 ug/mL。

5-Heneicosylresorcinol shows inhibitory effects on the release of β-hexosaminidase from RBL-2H3 cells, it also prevents triglyceride accumulation in 3T3-L1 cells. 5-Heneicosylresorcinol has nematicidal activity against nematodes Panagrellus redivivus, Caenothabditis elegans and Bursaphelenchus xylophilus, with ED50 values of 80, 30, and 180 ug/mL, respectively.(In Vitro):Alkylresorcinols are phenolic lipids present at levels of 0.03-0.15% in wheat and rye grains and almost 10 times higher in respective bran products. Despite numerous studies on the influence of dietary fibers on the regulation of energy metabolism, this issue still remains controversial. METHODS AND RESULTS: The objective of our current studies was to investigate whether 5-n-alk(en)ylresorcinols, natural phenolic components of high fiber human diets, may be considered as natural regulators of excessive fat accumulation. Our studies revealed that 5-n-alk(en)ylresorcinols isolated from wheat and rye bran inhibit glycerol-3-phosphate dehydrogenase, the key enzyme in triglyceride synthesis in adipocytes, specifically and effectively. Further in vitro studies showed that these compounds also prevent triglyceride accumulation in 3T3-L1 cells. CONCLUSIONS: The most effective compound in both systems was 5-n-heneicosylresorcinol(5-Heneicosylresorcinol). The results indicate that the potential to prevent triglyceride accumulation increases with the hydrophobicity of the phenolic inhibitor.

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Membrane Transporter/Ion Channel

NADPH

NADPH

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70110-59-7

404.66

C27H48O2

>98% (HPLC)

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CCCCCCCCCCCCCCCCCCCCCc1cc(O)cc(O)c1

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(-20℃)

With Ice Pack

≥ 2 years