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Monastrol
CAS No. 329689-23-8
Monastrol ( ±)-Monastrol )
产品货号. M14088 CAS No. 329689-23-8
A potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14 uM (microtubule motility inhibition).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥446 | 有现货 |
|
| 5MG | ￥551 | 有现货 |
|
| 10MG | ￥753 | 有现货 |
|
| 25MG | ￥1539 | 有现货 |
|
| 50MG | ￥2592 | 有现货 |
|
| 100MG | ￥4625 | 有现货 |
|
| 500MG | ￥10125 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Monastrol
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14 uM (microtubule motility inhibition).
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产品描述A potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14 uM (microtubule motility inhibition); does not inhibit microtubule motility driven by conventional kinesin at 200 uM; inhibits both the basal and the microtubule-stimulated ATPase activity of the Eg5 motor domain, does not compete with ATP binding to Eg5; arrests cells in mitosis with monoastral spindles, and (S)-monastrol is a more potent inhibitor of Eg5 activity in vitro and in vivo.
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同义词±)-Monastrol
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通路Cytoskeleton/Cell Adhesion Molecules
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靶点Kinesin
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受体Eg5
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研究领域Cancer
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适应症——
化学信息
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CAS Number329689-23-8
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分子量292.35
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分子式C14H16N2O3S
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 33 mg/mL
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SMILESCCOC(=O)C1=C(NC(=S)NC1C2=CC(=CC=C2)O)C
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化学全称5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-, ethyl ester
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Mayer TU, et al. Science. 1999 Oct 29;286(5441):971-4.
2. Kapoor TM, et al. J Cell Biol. 2000 Sep 4;150(5):975-88.
3. DeBonis S, et al. Biochemistry. 2003 Jan 21;42(2):338-49.
4. Maliga Z, et al. Chem Biol. 2002 Sep;9(9):989-96.
2. Kapoor TM, et al. J Cell Biol. 2000 Sep 4;150(5):975-88.
3. DeBonis S, et al. Biochemistry. 2003 Jan 21;42(2):338-49.
4. Maliga Z, et al. Chem Biol. 2002 Sep;9(9):989-96.
产品手册
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