K-858

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

A potent, selective inhibitor of mitotic kinesin Eg5 ATPase activity with IC50 of 1.3 uM.

A potent, selective inhibitor of mitotic kinesin Eg5 ATPase activity with IC50 of 1.3 uM; displays >150-fold more selective for Eg5 than other members of the kinesin superfamily; induces mitotic arrest, apoptosis, and cell growth inhibition through the activation of the Mad2-mediated spindle checkpoint, and has no effect on microtubule polymerization; exhibits potent antitumor activity in xenograft models of cancer, and induces the accumulation of mitotic cells with monopolar spindles in tumor tissues.Breast Cancer Preclinical

K-858;K 858

Cytoskeleton/Cell Adhesion Molecules

Kinesin

Eg5ATPase

Cancer

Breast Cancer

72926-24-0

277.34

C13H15N3O2S

>98% (HPLC)

10 mM in DMSO

CC(NC1=NN(C(C)=O)C(C2=CC=CC=C2)(C)S1)=O

Acetamide, N-(4-acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)-

(-20℃)

With Ice Pack

≥ 2 years