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MK-6169
CAS No. 1620479-63-1
MK-6169 ( MK6169 | MK 6169 )
产品货号. M12381 CAS No. 1620479-63-1
MK-6169 是一种有效的泛基因型 HCV NS5A 抑制剂，复制子 EC90 为 1-33 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥7857 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称MK-6169
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述MK-6169 是一种有效的泛基因型 HCV NS5A 抑制剂，复制子 EC90 为 1-33 nM。
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产品描述MK-6169 is a potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 1-33 nM, retains potency against common resistance-associated substitutions in the major genotypes; shows <10X shift on a majority of the genotypes and mutants tested, other than several mutants, such as GT3a Y93H and GT3a L31V, also show good potency on prototypical GT1a NS3 RASs such as GT1a R155K and GT1a V36M+R155K double substitution, as well as prototypical GT1b NS3 RASs such as GT1b A156T and GT1b D168Y; exhibits good pharmacokinetics in both rat and dog.
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体外实验——
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体内实验——
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同义词MK6169 | MK 6169
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通路Microbiology/Virology
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靶点HCV
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受体HCV
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研究领域——
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适应症——
化学信息
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CAS Number1620479-63-1
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分子量1016.203
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分子式C54H62FN9O8S
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(OC)N[C@@H]([C@H]1CC(C)(C)OCC1)C(N2[C@H](C3=NC=C(C4=CC5=C(N([C@H](C6=CC=C(C7CC7)S6)OC8=CC(C9=CN=C([C@H]%10N(C([C@H](C(C)C)NC(OC)=O)=O)CCC%10)N9)=CC(F)=C8%11)C%11=C5)C=C4)N3)CCC2)=O
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化学全称Methyl ((S)-2-((S)-2-(5-((S)-6-(5-cyclopropylthiophen-2-yl)-1-fluoro-3-(2-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-10-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-((R)-2,2-dimethyltetrahydro-2H-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Yu W, et al. J Med Chem. 2018 Apr 21. doi: 10.1021/acs.jmedchem.7b01927.
