BI-1388 ( BI1388;BI 1388 )

产品货号. M11240 CAS No. 1309952-03-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

BI-1388
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

BI-1388 is a potent, specific, macrocyclic inhibitor of HCV NS3 protease, inhibits viral replication for various HCV genotypes and for resistant mutants D168V and R155K.
产品描述

BI-1388 is a potent, specific, macrocyclic inhibitor of HCV NS3 protease, inhibits viral replication for various HCV genotypes and for resistant mutants D168V and R155K; BI-1388 was shown to be highly selective against other serine/cysteine proteases, binds to the active site of NS3 that is located in the shallow and broad protein-protein interaction surface of the protease- and the helicase domain of the enzyme.
同义词

BI1388;BI 1388
通路

Microbiology/Virology
靶点

HCV
受体

HCV
研究领域

——
适应症

——

CAS Number

1309952-03-1
分子量

819.98
分子式

C41H53N7O9S
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C([C@]([C@@]1([H])/C=C\CCCCC[C@@H]2NC(C3=NN(C)C=C3)=O)(C1)NC([C@@](C[C@@H](OC4=CC(OC(C)C)=NC5=C(C)C(OC)=CC=C45)C6)([H])N6C2=O)=O)NS(=O)(C7(C)CC7)=O
化学全称

(2R,6S,13aR,14aR,16aS,Z)-2-((2-Isopropoxy-7-methoxy-8-methylquinolin-4-yl)oxy)-6-(1-methyl-1H-pyrazole-3-carboxamido)-N-((1-methylcyclopropyl)sulfonyl)-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacycl

1. Tsantrizos YS, et al. Angew Chem Int Ed Engl. 2003 Mar 28;42(12):1356-60.

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产品手册

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