Resolvin D1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Resolvin D1 (RvD1) 是炎症的一种内源性促分解介质，衍生自在急性炎症的缓解阶段的 omega-3二十二碳六烯酸。Resolvin D1 通过调节肌动蛋白聚合来阻止促炎性中性粒细胞迁移，减少巨噬细胞中 TNF-α 介导的炎症，并增强巨噬细胞对凋亡细胞的吞噬作用。

Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages.

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Animal Model:18-20?g thirty 8-week-old female DBA/1J mice (collagen antibody-induced arthritis (CAIA))Dosage:100, 500, and 1000?ng (or 1000 ng, daily on days 4-10)Administration:i.p. injection; daily on days 10Result:Exhibit a reduced arthritic score.

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Apoptosis

Apoptosis

Apoptosis

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872993-05-0

376.49

C22H32O5

>98% (HPLC)

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[C@@H]([C@@H](/C=C/C=C/C=C\C=C\[C@H](C/C=C\CC)O)O)(C/C=C\CCC(O)=O)O

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(-20℃)

With Ice Pack

≥ 2 years