Pitstop 2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Pitstop 2 是一种网格蛋白抑制剂，通过与网格蛋白末端结构域结合来抑制网格蛋白介导的内吞作用 (CME)。它具有抗癌研究的潜力。

Pitstop 2 is a inhibitor of clathrin, and inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. It has the potential for anti-cancer research.

Pitstop 2 (20-40 μM; 30 min) inhibits the endocytosis of transferrin in J774A.1 macrophages and does not compromise cell viability.Pitstop 2 (20-40 μM; 30 min) does not affect the internalization of cholera toxin B in J774A.1 macrophages.Pitstop 2 (0.001-100 μM; 6 h) inhibits the mitotic spindle and impairs mitotic progression in HeLa cells.Pitstop 2 (1-30 μM; 24 h) induces apoptosis and inhibits cell growth in dividing cancer cells.Pitstop 2 (1-30 μM; 48 h) does not affect the growth and viability of non-tumourigenic NIH3T3 fibroblasts. Cell Viability Assay Cell Line:HeLa cells Concentration:1, 3, 10, 30 μM Incubation Time:24 hours Result:Reduced the total number of viable HeLa cells markedly in a dose-dependent manner.

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Apoptosis

Apoptosis

Apoptosis

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1419320-73-2

473.36

C20H13BrN2O3S2

>98% (HPLC)

DMSO : 62.5 mg/mL (132.03 mM; Need ultrasonic)

O=S(C1=C2C=CC=CC2=CC=C1)(NC(S/C3=C\C4=CC=C(Br)C=C4)=NC3=O)=O.[(Z)]

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(-20℃)

With Ice Pack

≥ 2 years