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Batabulin
CAS No. 195533-53-0
Batabulin ( T138067 )
产品货号. M23886 CAS No. 195533-53-0
Batabulin 是一种抗肿瘤化合物，它与 β-微管蛋白同种型的子集共价且选择性结合，从而破坏微管聚合。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1169 | 有现货 |
|
| 10MG | ￥1739 | 有现货 |
|
| 25MG | ￥2939 | 有现货 |
|
| 50MG | ￥4334 | 有现货 |
|
| 100MG | ￥5841 | 有现货 |
|
| 500MG | ￥11520 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥941 | 有现货 |
|
生物学信息
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产品名称Batabulin
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Batabulin 是一种抗肿瘤化合物，它与 β-微管蛋白同种型的子集共价且选择性结合，从而破坏微管聚合。
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产品描述Batabulin is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to cell-cycle arrest ultimately induce apoptotic cell death.
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体外实验Cell Cycle Analysis Cell Line:MCF7 cells Concentration:30 nM, 100 nM and 300 nM Incubation Time:24 hours Result:Showed an arrest at the G2/M cell-cycle boundary.Apoptosis Analysis Cell Line:MCF7 cells Concentration:30 nM, 100 nM and 300 nM Incubation Time:24 hours or 48 hours Result:25-30% of cells showed the reduced DNA content characteristic of apoptotic cells.
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体内实验Animal Model:Male athymic nude mice (nu/nu) (6-8 week-old, 20-25 g) injected with CCRF-CEM cells Dosage:40 mg/kg Administration:Intraperitoneal injection; once per week; on days 5, 12, and 19 Result:Impaired the growth of the drug-sensitive CCRF-CEM tumors.
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同义词T138067
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通路Apoptosis
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靶点Apoptosis
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受体Apoptosis|Tubulin β
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研究领域——
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适应症——
化学信息
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CAS Number195533-53-0
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分子量371.26
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分子式C13H7F6NO3S
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纯度>98% (HPLC)
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溶解度DMSO:100 mg/mL (269.35 mM; Need ultrasonic)
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SMILESO=S(C1=C(F)C(F)=C(F)C(F)=C1F)(NC2=CC=C(OC)C(F)=C2)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Shan B, et al. Selective, covalent modification of beta-tubulin residue Cys-239 by T138067, an antitumor agent with in vivo efficacy against multidrug-resistant tumors. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5686-91.
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