Clitocine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Clitocine 是一种来源于蘑菇的腺苷核苷类似物，是一种有效的通读剂 (readthrough)。Clitocine 作为一种无义突变 (nonsense mutations) 的抑制剂，可诱导携带 p53 无义突变等位基因的细胞产生 p53 蛋白。Clitocine 可通过靶向 Mcl-1 诱导多药耐药肿瘤细胞凋亡。具有抗癌活性。

Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity.

Clitocine incorporation into mRNA is required for premature stop codon readthrough activity, and the presence of clitocine at the third position of a premature stop codon is sufficient to promote robust readthrough.Clitocine (0-0.8 μM; 24 hours) enhances TRAIL-lethality in in LS411N and SW620 cells. Clitocine (0.2μM; 36 hours) significantly potentiates TRAIL-mediated apoptosis.

Citocine (0.3-3 mg/kg; s.c.; five times per week)-induced p53 inhibits CAOV-33p53-UAA136 tumor growth in a xenograft model.Animal Model:nu/nu mice (CAOV-3p53-UAA136 xenograft tumors)Dosage:0.3, 3 mg/kg (or 20 mg/kg once per week) Administration:S.c.; five times per weekResult:CAOV-33p53-UAA136 tumor growth was inhibited.

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Apoptosis

Apoptosis

Apoptosis | BCL

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105798-74-1

287.23

C9H13N5O6

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (348.15 mM; 超声助溶 )

Nc1ncnc(N[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1[N+]([O-])=O

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(-20℃)

With Ice Pack

≥ 2 years