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Clitocine
CAS No. 105798-74-1
Clitocine ( —— )
产品货号. M34550 CAS No. 105798-74-1
Clitocine 是一种来源于蘑菇的腺苷核苷类似物，是一种有效的通读剂 (readthrough)。Clitocine 作为一种无义突变 (nonsense mutations) 的抑制剂，可诱导携带 p53 无义突变等位基因的细胞产生 p53 蛋白。Clitocine 可通过靶向 Mcl-1 诱导多药耐药肿瘤细胞凋亡。具有抗癌活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Clitocine
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Clitocine 是一种来源于蘑菇的腺苷核苷类似物，是一种有效的通读剂 (readthrough)。Clitocine 作为一种无义突变 (nonsense mutations) 的抑制剂，可诱导携带 p53 无义突变等位基因的细胞产生 p53 蛋白。Clitocine 可通过靶向 Mcl-1 诱导多药耐药肿瘤细胞凋亡。具有抗癌活性。
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产品描述Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity.
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体外实验Clitocine incorporation into mRNA is required for premature stop codon readthrough activity, and the presence of clitocine at the third position of a premature stop codon is sufficient to promote robust readthrough.Clitocine (0-0.8 μM; 24 hours) enhances TRAIL-lethality in in LS411N and SW620 cells. Clitocine (0.2μM; 36 hours) significantly potentiates TRAIL-mediated apoptosis.
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体内实验Citocine (0.3-3 mg/kg; s.c.; five times per week)-induced p53 inhibits CAOV-33p53-UAA136 tumor growth in a xenograft model.Animal Model:nu/nu mice (CAOV-3p53-UAA136 xenograft tumors)Dosage:0.3, 3 mg/kg (or 20 mg/kg once per week) Administration:S.c.; five times per weekResult:CAOV-33p53-UAA136 tumor growth was inhibited.
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同义词——
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通路Apoptosis
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靶点Apoptosis
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受体Apoptosis | BCL
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研究领域——
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适应症——
化学信息
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CAS Number105798-74-1
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分子量287.23
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分子式C9H13N5O6
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (348.15 mM; 超声助溶 )
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SMILESNc1ncnc(N[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1[N+]([O-])=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Friesen WJ, et al. The nucleoside analog clitocine is a potent and efficacious readthrough agent. RNA. 2017;23(4):567-577.?
产品手册
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