2,5-dimethyl Celecoxib

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

2,5-二甲基塞来昔布是一种塞来昔布衍生物，也是微粒体前列腺素 E 合酶-1 (mPGES-1) 的靶向抑制剂，微粒体前列腺素 E 合酶-1 是炎症介质 PGE2 合成途径中的关键酶。

2,5-dimethyl Celecoxib is a celecoxib derivative and a targeted inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), a key enzyme in the PGE2 synthesis pathway of inflammatory mediators.(In Vitro):2,5-dimethyl Celecoxib(1–100?μM) decreased the viability of GBM cell lines in a dose-dependent manner. 2,5-dimethyl Celecoxib downregulated β-catenin target genes expression in A-172, T98G and U-138 MG cell lines. Apoptosis was induced, and cell cycle distribution was altered after the treatment with 2,5-dimethyl Celecoxib in T98G cell line.2,5-dimethyl Celecoxib downregulated β-catenin target genes expression in patient-derived primary GBM cell lines P1 and P6.(In Vivo):2,5-dimethyl Celecoxib prevented cardiac remodeling and markedly reduced urinary albumin excretion without altering blood pressure in mice. 2,5-dimethyl Celecoxib prevented podocyte injury, glomerulosclerosis, and interstitial fibrosis in the kidney of mice loaded with angiotensin II and high-salt load. 2,5-dimethyl Celecoxib reduced the phosphorylation level of Akt and activated glycogen synthase kinase-3, which led to the suppression of the Wnt/β-catenin signal in the heart and kidney. 2,5-dimethyl Celecoxib also reduced the expression level of snail, a key transcription factor for the epithelial–mesenchymal transition and of which gene is a target of the Wnt/β-catenin signal.

——

——

Celecoxib-13 | Celecoxib Impurity 42 | Celecoxib Impurity K

Apoptosis

Apoptosis

Glucocorticoid Receptor

——

——

457639-26-8

395.4

C18H16F3N3O2S

>98% (HPLC)

——

Cc1ccc(C)c(c1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F

——

(-20℃)

With Ice Pack

≥ 2 years