Hirsutanonol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Hirsutanonol 是桤木树皮的次生代谢产物。 Hirsutanonol 具有有效的抗氧化和自由基清除活性，并对线粒体脂质过氧化具有抑制作用。 Hirsutanonol 可用于研究

Hirsutanonol is a secondary metabolite from the bark of Alnus glutinosa. Hirsutanonol has potent antioxidant and free radical scavenging activities and exhibits an inhibition effect on mitochondrial lipid peroxidation. Hirsutanonol can be used for studies(In Vitro):Hirsutanonol shows significant inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression in immortalized human breast epithelial MCF10A cells. Hirustenone and hirsutanonol show promising anti-filarial activity both in vitro and in vivo studies.Hirsutanonol shows potent cytotoxic activities against murine B16 melanoma cells and human SNU-C1 gastric cancer cells, it also has a chemoprotective effect on human lymphocyte DNA. Hirsutanonol (1 μg/mL) decreased the frequency of micronuclei by 63.6 %, exerting a much stronger effect than the synthetic protector amifostine (17.2 %, 1 μg/mL).

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Chromatin/Epigenetic

COX

COX

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41137-86-4

346.4

C19H22O6

>98% (HPLC)

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O[C@@H](CCc1ccc(O)c(O)c1)CC(=O)CCc1ccc(O)c(O)c1

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(-20℃)

With Ice Pack

≥ 2 years