6-paradol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

6-paradol 是生姜和其他姜科植物中发现的一种刺激性酚类物质，具有多种生物活性，包括抗癌、抗炎、抗氧化、神经保护作用。

6-paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants and exhibits a variety of biological activities including anti-cancer anti-inflammatory and anti-oxidative activitiesneuroprotective Effects.

Paradol (-paradol) induces apoptosis in an oral squamous carcinoma cell line, KB, in a dose-dependent manner. Paradol induces apoptosis through a caspase-3-dependent mechanism.

Administration of Paradol (6-paradol) (10 mg/kg) clearly reduces the number of Iba1-positive cells 1 and 3 days after the challenge. Moreover, Paradol dramatically reduces the number of Iba1-postive cells in periischemic regions even after 3 days following M/R challenge. Paradol (6-paradol) exhibits the strongest anti-inflammatory effect of several paradol compounds in lipopolysaccharide-stimulated BV2 microglia derived from a mouse brain, including 2-, 4-, 6-, 8-, and 10-paradol. Furthermore, Paradol shows the strongest pungency of all of the known paradol analogues. Paradol also shows the highest contact time at the antiobesity site of action on the basis of the results shown for the absorption of the metabolites in this study.

Paradol | [6]-Gingerone

Chromatin/Epigenetic

COX

COX-2

——

——

27113-22-0

278.39

C17H26O3

>98% (HPLC)

DMSO:140 mg/mL (502.89 mM)

CCCCCCCC(=O)CCc1ccc(O)c(OC)c1

1-(4-Hydroxy-3-methoxyphenyl)decan-5-one

(-20℃)

With Ice Pack

≥ 2 years