COX
The cyclooxygenase (COX) enzymes have elaborate roles in human physiology and pathology, spanning the cardiovascular, neuronal, renal, immune, gastrointestinal and reproductive systems.The cyclooxygenase isoenzymes, COX-1 and COX-2, catalyze the formation of prostaglandins, thromboxane, and levuloglandins. COX enzymes are clinically important because they are inhibited by aspirin and numerous other non-steroidal anti-inflammatory drugs. COX-2 induction involves the orchestration of membrane-to-nucleus signaling processes such as tyrosine kinases, protein kinase C isoforms, peroxisome proliferator activated receptor, ras, NF-kB, and other transcription factors. Many of these converge on the mitogen activated protein kinase (MAPK) pathway involved in the transcriptional regulation of inflammatory genes. High expression of COX-2 in many tumors derives, in part, from somatic mutations that persistently activate signaling pathways for COX-2 expression.
References
1.Fitzpatrick FA. Curr Pharm Des. 2004;10(6):577-88.
References
1.Fitzpatrick FA. Curr Pharm Des. 2004;10(6):577-88.
Chromatin/Epigenetic
COX
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(+)-Catechin pentaacetate
产品货号 : M37765
cas no: 16198-01-9
(+)-Catechin pentaacetate 是生产 (+) catechin (HY-N0898 ) 的前体。(+) catechin 是一种有用的天然除草剂和抗菌剂。(+) catechin 抑制环加氧酶-1 (COX-1), IC50 为 1.4 μM。 -
TNF/IFNγ-IN-1
产品货号 : M37330
cas no: 876013-29-5
TNF/IFN-γ-IN-1 (compound TGA) 是 TNF 和 IFN-γ 的双重抑制剂。TNF/IFN-γ-IN-1 可用于阿尔茨海默病研究。 -
hCYP3A4 Fluorogenic substrate 1
产品货号 : M37062
cas no: 186299-00-3
hCYP3A4 Fluorogenic substrate 1 是一种强效 hCYP3A4 荧光底物,Km 值为 0.36 μM。hCYP3A4 Fluorogenic substrate 1 可用于细胞和体内成像。 -
COX-2-IN-34
产品货号 : M36994
cas no: 2788578-71-0
COX-2-IN-34 (compound 8a) 是一种选择性的、口服有效的 COX-2 抑制剂,无胃溃疡毒性,有抗炎作用。 -
Feladilimab
产品货号 : M36892
cas no: 2252518-85-5
Feladilimab (Anti-ICOS/CD278 Reference Antibody (feladilimab); GSK3359609) 是人源化的 IgG4,为抗 ICOS 激动剂单克隆抗体。Feladilimab 与表达 ICOS 的 T 细胞结合。Feladilimab 具有癌症研究的潜力。