HAT
A histone acetyltransferase (HAT) can be defined as an enzyme that acetylates core histones, which results in important regulatory effects on chromatin structure and assembly, and gene transcription. HATs are evolutionarily conserved from yeast to humans, that HATs generally contain multiple subunits, and that the functions of the catalytic subunit depend largely on the context of the other subunits in those complexes. Histone acetylation is a dynamic reversible process. The balance of histone acetylation is important for proper cellular function and the cell has evolved enzymes that catalyse the removal of acetyl groups, termed histone deacetylases (HDACs). Histone acetyltransferases are a diverse set of enzymes that can be grouped on the basis of their catalytic domains. Some subunits have domains that cooperate to recruit the HAT to the appropriate location in the genome; these include bromodomains, chromodomains, WD40 repeats, Tudor domains and PHD fingers.
References
1.Lee KK and Workman JL. Nat Rev Mol Cell Biol. 2007;8(4):284–295.
References
1.Lee KK and Workman JL. Nat Rev Mol Cell Biol. 2007;8(4):284–295.
Chromatin/Epigenetic
HAT
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CPTH6 hydrobromide
产品货号 : M17047
cas no: ——
CPTH6 Hydrobromide 是一种噻唑衍生物,可以降低人白血病细胞中的组蛋白乙酰化和组蛋白乙酰转移酶 (HAT) 活性。 -
Garcinol
产品货号 : M15966
cas no: 78824-30-3
Garcinol (Camboginol) 是体外和体内组蛋白乙酰转移酶 (HAT) p300 (IC50=7 uM) 和 PCAF (IC50=5 uM) 的有效天然抑制剂。 -
TTK21
产品货号 : M15723
cas no: 709676-56-2
TTK21(CBP-p300 激活剂 TTK21)是一种 CBP/p300 组蛋白乙酰转移酶活性的小分子激活剂,在浓度为 275 uM 时发挥最大作用。 -
CTPB
产品货号 : M15161
cas no: 586976-24-1
CTPB 是漆树酸衍生物,据报道是 p300 (KAT3B) HAT 活性的选择性激活剂,但不是 PCAF (KAT2B) 的激活剂。 -
CPTH2
产品货号 : M14229
cas no: 357649-93-5
CPTH2 是一种特异性组蛋白乙酰转移酶抑制剂,可在体外和体内调节 Gcn5 网络。