Naproxen

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Naproxen 是 COX-1 和 COX-2 的 COX 抑制剂，IC50 分别为 8.7 μM 和 5.2 μM。

Naproxen is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.(In Vitro):Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively.(In Vivo):Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC50=27, 40, 13 μM).

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(S)-Naproxen

Chromatin/Epigenetic

COX

COX

Inflammation/Immunology

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22204-53-1

230.27

C14H14O3

>98% (HPLC)

Soluble in Ethanol

O=C(O)[C@@H](C)C1=CC=C2C=C(OC)C=CC2=C1

(S)-2-(6-methoxynaphthalen-2-yl)propanoic acid

(-20℃)

With Ice Pack

≥ 2 years