Soyasapogenol B

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Soyasapogenol B 具有抗癌、降胆固醇、抗补体、保肝作用，可抑制培养的 Hep-G2 的增殖。

Soyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2.

Cell Viability Assay Cell Line:HCT116, SW480 Concentration:5, 10, 20 μM Incubation Time:24, 48 h Result:Decreased the viability of tumor cells.Western Blot Analysis Cell Line:HCT116, SW480 Concentration:10, 20 μM Incubation Time:48 h Result:Increased the level of caspase-3 and PARP.Decreased the expression of Bcl-2 and increased the expression of Bax.Increased the expression of LC3-II/LC3-I, Beclin 1 and Atg5, decreased the expression of p62.Apoptosis Analysis Cell Line:HCT116, SW480 Concentration:10, 20 μM Incubation Time:48 h Result:Increased the number of TUNEL positive cells.Increased the apoptotic percentage in HCT116 cells by more than 4 folds and 9 folds respectively, elevated to over 10% and 20% in SW480 cells.

Animal Model:Xenograft murine modelsDosage:25 or 50 mg/kg Administration:i.p.Result:Increased the apoptotic cell death dose-dependently.Increased the expression of cleaved caspase-3, Bax, CHOP, GRP78 and LC3BII.Decreased the expression of Bcl-2 and Ki-67.Animal Model:Lipopolysaccharide-induced memory impairment in mice Dosage:10 mg/kg Administration:p.o.Result:Increased LPS-suppressed BDNF expression and inhibited NF-κB activation and TNF-α expression.

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Apoptosis

Apoptosis

Apoptosis|Autophagy

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595-15-3

458.7

C30H50O3

>98% (HPLC)

DMSO:10 mM

C[C@]12[C@]3(C([C@@]4([H])[C@](C)([C@@H](CC(C)(C)C4)O)CC3)=CC[C@]1([H])[C@@]5([C@@]([C@](C)([C@@H](O)CC5)CO)([H])CC2)C)C

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(-20℃)

With Ice Pack

≥ 2 years