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Trk-IN-9
CAS No. 2758623-12-8
Trk-IN-9 ( —— )
产品货号. M35671 CAS No. 2758623-12-8
Trk-IN-9 (Compound 12) 是一种有效的 TRK 抑制剂。Trk-IN-9 抑制 Km-12 细胞系的增殖。Trk-IN-9 以浓度依赖性方式诱导 Km-12 细胞凋亡。Trk-IN-9 抑制 TRK 的磷酸化以阻断下游通路。Trk-IN-9具有研究NTRK融合癌症的潜力。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1511 | 有现货 |
|
| 10MG | ￥2261 | 有现货 |
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| 25MG | ￥3711 | 有现货 |
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| 50MG | ￥5292 | 有现货 |
|
| 100MG | ￥7011 | 有现货 |
|
| 500MG | ￥17820 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Trk-IN-9
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Trk-IN-9 (Compound 12) 是一种有效的 TRK 抑制剂。Trk-IN-9 抑制 Km-12 细胞系的增殖。Trk-IN-9 以浓度依赖性方式诱导 Km-12 细胞凋亡。Trk-IN-9 抑制 TRK 的磷酸化以阻断下游通路。Trk-IN-9具有研究NTRK融合癌症的潜力。
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产品描述Trk-IN-9 (Compound 12) is a potent inhibitor of TRK. Trk-IN-9 inhibits the proliferation of Km-12 cell lines. Trk-IN-9 induces the apoptosis of Km-12 cells in a concentration-dependent manner. Trk-IN-9 inhibits the phosphorylation of TRK to block downstream pathways. Trk-IN-9 has the potential for the research of NTRK-fusion cancers.
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体外实验——
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体内实验——
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同义词——
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通路Apoptosis
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靶点Apoptosis
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受体Apoptosis | Trk receptor
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研究领域——
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适应症——
化学信息
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CAS Number2758623-12-8
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分子量454.93
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分子式C23H24ClFN6O
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纯度>98% (HPLC)
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溶解度——
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SMILESN(C=1N=C(NCC2=CC(F)=CC=C2)C(Cl)=CN1)C3=CC(C(N[C@@H]4CCCNC4)=O)=CC=C3
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Wu T, et al. Rational drug design to explore the structure-activity relationship (SAR) of TRK inhibitors with 2,4-diaminopyrimidine scaffold. Eur J Med Chem. 2022;230:114096.?
产品手册
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