1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SC-1 是多种酪氨酸激酶抑制剂索拉非尼的衍生物。 SC-1 通过阻断 STAT3 磷酸化和激活来有效抑制 STAT3 磷酸化，并诱导肝细胞癌细胞系凋亡。

SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib. SC-1 potently inhibits the phosphorylation of STAT3 by blocking STAT3 phosphorylation and activation, and induces apoptosis in hepatocellular carcinoma cell lines.(In Vitro):SC-1(1-10 μM; 48 hours; breast cancer cells) treatment demonstrates dose-dependent suppression of cell viability in all tested breast cancer cells. SC-1(1-10 μM; 36 hours; breast cancer cells) treatment induces potent apoptotic activity in association with downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines.(In Vivo):SC-1 showes efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors in vivo.

STAT3-IN-7 (SC-1; 1-10 μM; 48 hours; breast cancer cells) treatment demonstrates dose-dependent suppression of cell viability in all tested breast cancer cells.STAT3-IN-7 (SC-1; 1-10 μM; 36 hours; breast cancer cells) treatment induces potent apoptotic activity.STAT3-IN-7 (SC-1; 1-10 μM; 36 hours; breast cancer cells) treatment shows downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines. Cell Viability AssayCell Line:HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells Concentration:1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM Incubation Time:48 hours Result:Demonstrated dose-dependent suppression of cell viability in all tested breast cancer cells.Apoptosis Analysis Cell Line:HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells Concentration:1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM Incubation Time:36 hours Result:Induced potent apoptotic activity.Western Blot Analysis Cell Line:HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells Concentration:1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM Incubation Time:36 hoursResult:Showed downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines.

STAT3-IN-7 (10 mg/kg; oral gavage; daily; for 28 days; female NCr athymic nude mice) treatment shows efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors. Animal Model:Female NCr athymic nude mice (4-6 weeks of age) injected with breast cancer cells Dosage:10 mg/kg Administration:Oral gavage; daily; for 28 days Result:Showed efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors.

SC-1

Apoptosis

Apoptosis

HCV|Bacterial|Apoptosis|Fungal

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1313019-65-6

431.8

C21H13ClF3N3O2

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (578.97 mM)

N#Cc(cc1)ccc1Oc(cc1)ccc1NC(Nc(cc1)cc(C(F)(F)F)c1Cl)=O

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(-20℃)

With Ice Pack

≥ 2 years