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Flunixin meglumin
CAS No. 42461-84-7
Flunixin meglumin ( NIH 10250 )
产品货号. M14442 CAS No. 42461-84-7
Flunixin Meglumin 是一种有效的环氧合酶抑制剂，用作镇痛剂，具有抗炎和解热活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | ￥104 | 有现货 |
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| 500MG | ￥226 | 有现货 |
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| 1G | ￥363 | 有现货 |
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| 1 mL x 10 mM in DMSO | ￥109 | 有现货 |
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生物学信息
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产品名称Flunixin meglumin
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Flunixin Meglumin 是一种有效的环氧合酶抑制剂，用作镇痛剂，具有抗炎和解热活性。
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产品描述Flunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase used as analgesic agent with anti-inflammatory and antipyretic activity.(In Vitro):flunixin meglumine (10-1000 μM, 2 h) inhibits lipopolysaccharide (LPS)-induced activity of inducible nitric oxide synthase (iNOS) in RAW 264.7 murine macrophages.flunixin meglumine (10-1000 μM, 2 h) inhibits lipopolysaccharide-induced activation of nuclear factor kappa B (NfκB) in RAW 264.7 murine macrophages.(In Vivo):Flunixin meglumine (intravenous injection; 1.1 mg/kg; once) treatment inhibits the formation of exudate PGE2 and serum TXB2.
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体外实验flunixin meglumine (10-1000 μM, 2 h) inhibits lipopolysaccharide (LPS)-induced activity of inducible nitric oxide synthase (iNOS) in RAW 264.7 murine macrophages.flunixin meglumine (10-1000 μM, 2 h) inhibits lipopolysaccharide-induced activation of nuclear factor kappa B (NfκB) in RAW 264.7 murine macrophages. Cell Viability Assay Cell Line:RAW 264.7 murine macrophages Concentration:10, 100, 300, and 1000 μM Incubation Time:2 hours Result:Inhibited LPS-induced nitric oxide release at concentrations between 100 and 1,000 μM (P=0.01).
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体内实验Flunixin meglumine (intravenous injection; 1.1 mg/kg; once) treatment inhibits the formation of exudate PGE2 and serum TXB2. Animal Model:Male sheep injected with Carrageenan Dosage:1.1 mg/kg Administration:Intravenous injection; 1.1 mg/kg; once Result:Inhibited Carrageenan-induced exudate PGE2 formation (Emax, 100%, IC50, <0.4 nM) and serum TXB2 generation (Emax, 100%, IC50, 17 nM) for up to 32 h.
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同义词NIH 10250
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通路Chromatin/Epigenetic
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靶点COX
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受体COX-1| COX-2
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研究领域Inflammation/Immunology
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适应症——
化学信息
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CAS Number42461-84-7
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分子量491.46
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分子式C21H28F3N3O7
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纯度>98% (HPLC)
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溶解度Ethanol: 8 mg/mL (16.27 mM); Water: 98 mg/mL (199.4 mM); DMSO: 98 mg/mL (199.4 mM)
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SMILESO=C(C1=CC=CN=C1NC2=CC=CC(C(F)(F)F)=C2C)O.O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CNC
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化学全称(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol 2-((2-methyl-3-(trifluoromethyl)phenyl)amino)nicotinate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Duz M, et al. Am J Vet Res. 2015 Mar;76(3):208-15.
