Geldanamycin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Geldanamycin 是一种天然存在的 HSP90 抑制剂，Kd 为 1.2 μM，特异性破坏糖皮质激素受体 (GR)/HSP 关联。

Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.(In Vitro):Geldanamycin significantly delays and reduces viperin expression, indicating that IRF3 is involved in viperin induction in RAW264.7 cells. Geldanamycin (GA), a benzoquinone ansamycin, protected against neuronal injury induced by oxygen-glucose deprivation (OGD)/zVAD treatment in cultured primary neurons. More importantly, Geldanamycin decreases RIP1 protein level in a time and concentration-dependent manner. Geldanamycin also decreases the Hsp90 protein level, which causes instability of RIP1 protein, resulting in decreased RIP1 protein level but not RIP1 mRNA level after Geldanamycin treatment. Geldanamycin (GA) is identified as the first natural product inhibitor of Hsp90 that binds to the N-terminal ATPase domain of Hsp90 to inhibit its chaperone function, and significantly induces tumor cell death via an apoptotic mechanism.

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NSC 122750

Cytoskeleton/Cell Adhesion Molecules

HSP

HSP90| HSP90| p185

Cancer

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30562-34-6

560.64

C29H40N2O9

>98% (HPLC)

DMSO:50 mg/mL warmed (89.18 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)

NC(O[C@@H](/C(C)=C/[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)CC1=C2OC)[C@@H](OC)/C=C\C=C(C)\C(NC(C1=O)=CC2=O)=O)=O

(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

(-20℃)

With Ice Pack

≥ 2 years