YK5

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

YK5 是一种有效的选择性 Hsp70 抑制剂。YK5 在癌细胞中选择性地，紧密地与胞质 Hsp70s 结合。YK5 通过干扰活性致癌 Hsp70/Hsp90/ 配体蛋白复合物的形成而发挥其生物活性。

YK5 is a small molecule inhibitor of Hsp70 and Hsc70, induces the degradation of HER2, Raf-1, and Akt kinases, also induces apoptosis in the SKBr3 breast cancer cells.

YK5 shows selectively and tightly binds to the cytosolic Hsp70s.YK5 (0.5, 1, 5 μM; 72 h) degrades the expression of Hsp90/Hsp70-onco-client proteins and also leads to the inhibition of cell proliferation in SKBr3 cells.YK5 (0.5, 1, 5 μM; 24 h) induces the degradation of HER2, Raf-1, Akt kinases, and also induces apoptosis in SKBr3 cells. Cell Proliferation AssayCell Line:SKBr3 cells Concentration:0.5, 1, 5 μMIncubation Time:72 hResult:Degraded the expression of Hsp90/Hsp70-onco-client proteins and also led to the inhibition of cell proliferation in SKBr3 cells.Western Blot AnalysisCell Line:SKBr3 cellsConcentration:0.5, 1, 5 μM Incubation Time:24 h Result:Induced the degradation of HER2, Raf-1, Akt kinases, and also induced apoptosis in SKBr3 cells.

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YK5 | YK-5 | YK 5

Cytoskeleton/Cell Adhesion Molecules

HSP

HSP

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1268273-23-9

432.503

C18H24N8O3S

>98% (HPLC)

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C=CC(NC1=NC(SC2=C(OC)N=C(N3CCN(C)CC3)N=C2OC)=NC(N)=C1)=O

N-(6-amino-2-((4,6-dimethoxy-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)thio)pyrimidin-4-yl)acrylamide

(-20℃)

With Ice Pack

≥ 2 years