Arimoclomol ( BRX-220 free base )

产品货号. M26548 CAS No. 289893-25-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Arimoclomol
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Arimoclomol 是热休克蛋白 (HSP) 的共同诱导剂，可用于治疗肌萎缩侧索硬化症 (ALS) 的研究。
产品描述

Arimoclomol is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (ALS).(In Vivo):In male Wistar rats, Arimoclomol (20 mg/kg; gavage) protects cholecystokinin-octapeptide (CCK)-induced acute pancreatitis. The pancreatic levels of HSP60 and HSP72 are significantly increased.
体外实验

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体内实验

Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect againstcholecystokinin-octapeptide (CCK)-induced acute pancreatitis. Animal Model:Male Wistar rats weighing 240 to 270 gDosage:20 mg/kg Administration:Administered intragastrically, for 5 daysResult:Had a protective effect against CCK-induced acute pancreatitis.
同义词

BRX-220 free base
通路

Cytoskeleton/Cell Adhesion Molecules
靶点

HSP
受体

AP-1| LOX| NF-κB| Parasite
研究领域

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适应症

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1.Hadjipavlou-Litina D, et al. Kukoamine A analogs with lipoxygenase inhibitory activity. J Enzyme Inhib Med Chem. 2009 Oct;24(5):1188-93.

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