PU-H71 HCl ( —— )

产品货号. M36291 CAS No. 2095432-24-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

PU-H71 HCl
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT. PU-H71 HCL shows antitumor activity in many preclinical models of malignancy. PU-H71 HCL has an inhibitory effect on the protein expression levels of Rad51 and Ku70, which may be associated with the double chain break repair in the homologous recombination pathway and non-homologous end-joining pathway.
产品描述

PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT. PU-H71 HCL shows antitumor activity in many preclinical models of malignancy. PU-H71 HCL has an inhibitory effect on the protein expression levels of Rad51 and Ku70, which may be associated with the double chain break repair in the homologous recombination pathway and non-homologous end-joining pathway.
体外实验

——
体内实验

——
同义词

——
通路

Cytoskeleton/Cell Adhesion Molecules
靶点

HSP
受体

HSP | DNA/RNA Synthesis
研究领域

——
适应症

——

计算器

产品手册

关联产品

PU-H71

PU-H71 是一种有效的选择性 HSP90 抑制剂，IC50 为 51 nM。
GRP78-IN-3

GRP78-IN-3 是一种选择性 Grp78 (HSPA5) 抑制剂，IC50 为 0.59 μM。GRP78-IN-3 对 HspA5 的选择性是 HspA9 的 7 倍 (IC50 为 4.3 μM)，是 HspA2 的 20 倍以上 (IC50 为 13.9 μM)。
NVP-AUY922

一种有效的选择性 HSP90 抑制剂，对于 HSP90β 和 HSP90α 的 IC50 分别为 21 和 7.8 nM。