2',4'-DIHYDROXYCHALCONE

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

2',4'-二羟基查耳酮作为具有 Hsp90 抑制和抗真菌作用的化合物在 2',4'-DHC (8 g/mL) 存在下，与对照相比，烟曲霉的径向生长被抑制 20%，绿色色素沉着被彻底封锁。

2',4'-Dihydroxychalcone as a compound with Hsp90 inhibitory and antifungal effectsIn the presence of 2',4'-DHC (8 g/mL), radial growth of Aspergillus fumigatus was inhibited 20% compared to the control, and green pigmentation was completely blocked.?The expression of the conidiation-associated genes abaA, brlA, and wetA was significantly decreased (approximately 3- to 5-fold) by treatment with 2',4'-DHC.?The expression of calcineurin signaling components, cnaA and crzA, was also significantly reduced.?The inhibitory effects of 2',4'-DHC on metabolic activity and mycelial growth were significantly enhanced by combination treatment with itraconazole and caspofungin.?Docking studies indicated that 2',4'-DHC bind to the ATPase domain of Hsp90.?2',4'-DHC act as an Hsp90-calcinurin pathway inhibitor.

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2',4'-DHC

Cytoskeleton/Cell Adhesion Molecules

HSP

HSP90

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1776-30-3

240.25

C15H12O3?

>98% (HPLC)

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O=C(C1=CC=C(O)C=C1O)C=CC2=CC=CC=C2

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(-20℃)

With Ice Pack

≥ 2 years