AMP-PCP

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AMP-PCP 是 ATP 类似物，可以结合 Hsp90 N 末端结构域，Kd 值为 3.8 μM。 AMP-PCP 结合有利于 Hsp90 活性同二聚体的形成。

AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90.AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP.

AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP.

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Cytoskeleton/Cell Adhesion Molecules

HSP

HSP90

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3469-78-1

505.21

C??H??N?O??P?

>98% (HPLC)

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O[C@H]1[C@@H](O[C@H](COP(OP(CP(O)(O)=O)(O)=O)(O)=O)[C@H]1O)N2C3=C(C(N)=NC=N3)N=C2

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(-20℃)

With Ice Pack

≥ 2 years