YZ129

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

YZ129 (YZ-129) 是 HSP90-Calcineurin-NFAT 通路的小分子抑制剂，抑制 HeLa 细胞中 TG 诱导的 NFAT 核转位，IC50 为 820 nM。

YZ129 (YZ-129) is a small molecule inhibitor of HSP90-Calcineurin-NFAT pathway, suppresses TG-induced NFAT nuclear translocation in HeLa cellswith IC50 of 820 nM; also suppressed the expression of NFAT-regulated genes, such as COX2, MMP7, and MMP9, in U87 GBM cells; directly binds to HSP90 to antagonize its chaperoning effect on calcineurin, a Ca2+-sensitive phosphatase that is required for NFAT nuclear translocation and subsequent gene expression; YZ129 could not only suppress cancer cell growth but also reduce cancer cell movement and migration of of GBM cells in vitro; suppresses the growth of GBM xenografts in vivo.

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YZ-129 | YZ 129

Cytoskeleton/Cell Adhesion Molecules

HSP

HSP

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1643120-60-8

300.317

C19H12N2O2

>98% (HPLC)

In Vitro:?DMSO : 5.6 mg/mL (18.65 mM)

O=C(C1=CC=CC=C1C(NC2=CC=C(C=NC=C3)C3=C2)=C4)C4=O

4-(isoquinolin-6-ylamino)naphthalene-1,2-dione

(-20℃)

With Ice Pack

≥ 2 years