Periplocin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Periplocin 对肺癌细胞具有抗癌作用，通过 β-catenin/Tcf 信号通路诱导细胞凋亡并抑制癌细胞生长。

Periplocin has anti-cancer effects on lung cancer cells, induces apoptosis and inhibits growth of cancer cells by the beta-catenin/Tcf signaling pathway. Periplocin is used for treatment of rheumatoid arthritis, reinforcement of bones and tendons, palpitations or shortness of breath and lower extremity edema in traditional medicine.

Cell Viability Assay Cell Line:L929 cells Concentration:5 μM, 10 μM, 20 μM Incubation Time:48 hours Result:Showed increased proliferation up to 131% at 20 μM.Western Blot Analysis Cell Line:L929 cells Concentration:5 μM, 10 μM, 20 μM Incubation Time:30 minutes, 60 minutes, 120 minutes Result:Increased phosphorylation of Src, ERK, PI3K and Akt at active sites in a dosedependent and time-dependent manner.

Animal Model:Female SCID mice (6-8 weeks old) injected with Huh-7 cells Dosage:5 mg/kg, 20 mg/kg Administration:Intraperitoneal injection; daily; for 14 days Result:Repressed the growth of hepatocellular carcinoma (HCC) in xenograft tumor model in mice.

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Cytoskeleton/Cell Adhesion Molecules

HSP

Others

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13137-64-9

696.83

C36H56O13

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (143.51 mM)

CC1C(C(CC(O1)OC2CCC3(C4CCC5(C(CCC5(C4CCC3(C2)O)O)C6=CC(=O)OC6)C)C)OC)OC7C(C(C(C(O7)CO)O)O)O

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(-20℃)

With Ice Pack

≥ 2 years