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LY500307
CAS No. 533884-09-2
LY500307 ( LY-500307;LY 500307;Erteberel;SERBA-1 )
产品货号. M14897 CAS No. 533884-09-2
LY500307 (LY-500307, Erteberel, SERBA-1) is a potent, selective Estrogen Receptor β (ERβ) agonist with Ki/EC50 of 0.19/0.66 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1936 | 有现货 |
|
| 5MG | ￥3686 | 有现货 |
|
| 10MG | ￥5322 | 有现货 |
|
| 25MG | ￥7995 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称LY500307
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述LY500307 (LY-500307, Erteberel, SERBA-1) is a potent, selective Estrogen Receptor β (ERβ) agonist with Ki/EC50 of 0.19/0.66 nM.
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产品描述LY500307 (LY-500307, Erteberel, SERBA-1) is a potent, selective Estrogen Receptor β (ERβ) agonist with Ki/EC50 of 0.19/0.66 nM, 12-fold higher affinity than ERα and exhibits 32-fold more functional potency; reduces proliferation and induces apoptosis in GBM cells, enhances ERβ signaling and expression, modulates the expression of genes involved in cell cycle, cell death, survival, and DNA damage response; also sensitizes GBM cells to chemotherapeutic agents, reduces GBM progression in an orthotopic model .Schizophrenia Phase 2 Clinical
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同义词LY-500307;LY 500307;Erteberel;SERBA-1
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通路Endocrinology/Hormones
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靶点Estrogen Receptor/ERR
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受体ERβ
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研究领域Neurological Disease
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适应症Schizophrenia
化学信息
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CAS Number533884-09-2
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分子量282.34
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分子式C18H18O3
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纯度>98% (HPLC)
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溶解度——
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SMILESOC1=CC=C2C([C@@](CCC3)([H])[C@@]3([H])[C@H](C4=CC=C(O)C=C4)O2)=C1
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化学全称(3aS,4R,9bR)-1,2,3,3a,4,9b-Hexahydro-4-(4-hydroxyphenyl)cyclopenta[c][1]benzopyran-8-ol
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Sareddy GR, et al. Sci Rep. 2016 Apr 29;6:24185.
2. Norman BH, et al.
3. Zhao L, et al. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3673-E3681.
4. Reese JM, et al. Oncotarget. 2017 Oct 11;8(57):96506-96521.
2. Norman BH, et al.
3. Zhao L, et al. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3673-E3681.
4. Reese JM, et al. Oncotarget. 2017 Oct 11;8(57):96506-96521.
产品手册
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