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LY500307

CAS No. 533884-09-2

LY500307 ( LY-500307;LY 500307;Erteberel;SERBA-1 )

产品货号. M14897 CAS No. 533884-09-2

LY500307 (LY-500307, Erteberel, SERBA-1) is a potent, selective Estrogen Receptor β (ERβ) agonist with Ki/EC50 of 0.19/0.66 nM.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥1936 有现货
5MG ¥3686 有现货
10MG ¥5322 有现货
25MG ¥7995 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    LY500307
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    LY500307 (LY-500307, Erteberel, SERBA-1) is a potent, selective Estrogen Receptor β (ERβ) agonist with Ki/EC50 of 0.19/0.66 nM.
  • 产品描述
    LY500307 (LY-500307, Erteberel, SERBA-1) is a potent, selective Estrogen Receptor β (ERβ) agonist with Ki/EC50 of 0.19/0.66 nM, 12-fold higher affinity than ERα and exhibits 32-fold more functional potency; reduces proliferation and induces apoptosis in GBM cells, enhances ERβ signaling and expression, modulates the expression of genes involved in cell cycle, cell death, survival, and DNA damage response; also sensitizes GBM cells to chemotherapeutic agents, reduces GBM progression in an orthotopic model .Schizophrenia Phase 2 Clinical
  • 同义词
    LY-500307;LY 500307;Erteberel;SERBA-1
  • 通路
    Endocrinology/Hormones
  • 靶点
    Estrogen Receptor/ERR
  • 受体
    ERβ
  • 研究领域
    Neurological Disease
  • 适应症
    Schizophrenia

化学信息

  • CAS Number
    533884-09-2
  • 分子量
    282.34
  • 分子式
    C18H18O3
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    OC1=CC=C2C([C@@](CCC3)([H])[C@@]3([H])[C@H](C4=CC=C(O)C=C4)O2)=C1
  • 化学全称
    (3aS,4R,9bR)-1,2,3,3a,4,9b-Hexahydro-4-(4-hydroxyphenyl)cyclopenta[c][1]benzopyran-8-ol

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Sareddy GR, et al. Sci Rep. 2016 Apr 29;6:24185.
2. Norman BH, et al.
3. Zhao L, et al. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3673-E3681.
4. Reese JM, et al. Oncotarget. 2017 Oct 11;8(57):96506-96521.
产品手册
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