Mifepristone ( RU-486 )

产品货号. M16134 CAS No. 84371-65-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Mifepristone
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Mifepristone is a progestational and glucocorticoid hormone antagonist.
产品描述

Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary cushing syndrome.
同义词

RU-486
通路

Endocrinology/Hormones
靶点

Estrogen Receptor/ERR
受体

PR; Glucocorticoid Receptor
研究领域

Endocrinology
适应症

——

CAS Number

84371-65-3
分子量

429.60
分子式

C29H35NO2
纯度

>98%(HPLC)
溶解度

Ethanol: 19 mg/mL (44.22 mM); DMSO: 85 mg/mL (197.86 mM)
SMILES

O=C1CCC2=C3[C@@H](C4=CC=C(N(C)C)C=C4)C[C@]5(C)[C@@](C#CC)(O)CC[C@@]5([H])[C@]3([H])CCC2=C1
化学全称

(8S,11R,13S,14S,17S)-11-(4-(dimethylamino)phenyl)-17-hydroxy-13-methyl-17-(prop-1-yn-1-yl)-6,7,8,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one

1.Jiang W, et al. Bioorg Med Chem, 2006, 14(19), 6726-6732.

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