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LY2119620
CAS No. 886047-22-9
LY2119620 ( LY2119620 | LY 2119620 | LY-2119620 )
产品货号. M17642 CAS No. 886047-22-9
LY2119620 是人 M2 和 M4 毒蕈碱乙酰胆碱受体的特异性变构激动剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥591 | 有现货 |
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| 5MG | ￥1013 | 有现货 |
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| 10MG | ￥1604 | 有现货 |
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| 25MG | ￥3094 | 有现货 |
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| 50MG | ￥4609 | 有现货 |
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| 100MG | ￥6634 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称LY2119620
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述LY2119620 是人 M2 和 M4 毒蕈碱乙酰胆碱受体的特异性变构激动剂。
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产品描述LY2119620 is a positive allosteric modulator of the M2 and M4 muscarinic acetylcholine receptors (mAChRs).
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体外实验LY2119620 shows a modest allosteric agonism of 23.2±2.18% and 16.8±5.01% at the M2 and M4 receptors, respectively. Minimal allosteric agonism (<20%) is observed for LY2119620 at the M1, M3, and M5 receptors. The variable KB of LY2119620 for the allosteric binding site on the unoccupied receptor is found to be consistently about 1.9 to 3.4 μM.Results show a Bmax increase at the M2 receptor from 793±1.95 fmol/mg to 2850±162 fmol/mg upon addition of 10 μM LY2119620, and about a 5-fold increase in Bmax at the M4 receptor, 284±18.3 fmol/mg to 1340±42.2 fmol/mg.
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体内实验——
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同义词LY2119620 | LY 2119620 | LY-2119620
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通路Others
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靶点Other Targets
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受体M2 mAChR|M4 mAChR
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研究领域Neurological Disease
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适应症——
化学信息
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CAS Number886047-22-9
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分子量437.94
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分子式C19H24ClN5O3S
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纯度>98% (HPLC)
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溶解度DMSO : 67.5 mg/mL. 154.13 mM; H2O : < 0.1 mg/mL
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SMILESCN1CCN(CC1)C(=O)COc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl
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化学全称3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Croy C H, Schober D A, Xiao H, et al. Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M(2) and M(4) receptors.[J]. Molecular Pharmacology, 2014, 86(1):106-115.
