Loreclezole

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Loreclezole 是一种选择性 GABAA 受体调节剂，可作为含有 β2 或 β3 亚基的受体的正变构调节剂。

Loreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors.

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Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the “pull-up” test. Animal Model:Adult male Lister Hooded rats.Dosage:10, 25, 50 or 75 mg/kg.Administration:IP, 60 min before measurement of seizure threshold.Result:Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later.

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Others

Other Targets

GABAA

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117857-45-1

274.53

C10H6Cl3N3

>98% (HPLC)

DMSO: 90 mg/mL (327.83 mM)

Cl\C(=C/n1cncn1)c1ccc(Cl)cc1Cl

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(-20℃)

With Ice Pack

≥ 2 years