NSC622608

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NSC622608 是 T 细胞激活 V 域 Ig 抑制因子 (VISTA) 的小分子配体，VISTA 是影响 T 细胞攻击肿瘤能力的免疫检查点。

NSC622608 is a small-molecule ligand for V-domain Ig suppressor of T-cell activation (VISTA) which is an immune checkpoint that affects the ability of T-cells to attack tumors.(In Vitro):NSC622608 blocked VISTA signaling in vitro, enhanced T-cell proliferation, and restored T-cell activation in the presence of VISTA-expressing cancer cell lines.

NSC622608 disrupts VISTA-VSIG-3 interaction with an IC50 value of 9.7 ± 0.3 μM.

——

——

Others

Other Targets

Antifection|MMP|Leishmania tropica

——

——

2593254-90-9

322.24

C9H12BrN3OS2

>98% (HPLC)

In Vitro:?DMSO : 41.67 mg/mL (129.31 mM)

CN(C)C(SS1)=NC1=NCC2=CC=CO2.[H]Br

——

(-20℃)

With Ice Pack

≥ 2 years